1996 Dec 15; 98(12):2771-8. Mol Cell Biol. UCSD Profiles is managed by the UC San Diego 1999 Mar; 15(2):103-7. Hepatology. NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis. Am J Physiol Gastrointest Liver Physiol. 2008 Nov; 48(5):1420-9. TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein. 2019 10; 68(10):1884-1892. Am J Physiol Gastrointest Liver Physiol. J Trauma. 2012 Mar; 10(3):285-90.e1. 2006 May; 130(6):1564-72. Gastroenterology. Signal transduction during liver regeneration. Chojkier M, Flaherty M, Peterkofsky B, Majmudar GH, Spanheimer RG. Am J Physiol Gastrointest Liver Physiol. Scelzo A, Di Somma S, Antonini P, Montross LP. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Allergy. 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Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. Am J Physiol Gastrointest Liver Physiol. Role of NADPH oxidases in liver fibrosis. Novel association between serum pentraxin-2 levels and advanced fibrosis in well-characterised patients with non-alcoholic fatty liver disease. WebBrenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! Fibrogenesis Tissue Repair. 2005 Mar; 39(3):181-8. The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression. 1998 08; 275(2):G269-78. Lavalle PC, Labreuche J, Gongora-Rivera F, Jaramillo A. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. He did not respond to inewsource s interview request. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. 2006 Sep; 131(3):957-60. Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force. We lose people all of the time. Gut. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. Data from arrays: an embarrassment of riches. Proc Natl Acad Sci U S A. 2003 Mar; 37(3):653-64. Exercise training attenuates age-associated diastolic dysfunction in rats. This graph shows the total number of publications by year. 2010 Jul-Aug; 19(4):311-20. Techniques to measure nucleic acid-protein binding and specificity. 2015 Jul; 22(7):512-8. Gastroenterology. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. Hepatol Commun. 2001 Jan; 33(1):81-90. J Burn Care Rehabil. 2021 05; 134:105933. 2012 Nov; 143(5):1330-1340.e1. 2020 01 07; 31(1):189-206.e8. 2003 Jul 15; 76(1):28-37. 2017 10 10; 114(41):10808-10809. Clin Gastroenterol Hepatol. 1994 Oct 21; 269(42):26396-401. 1996 Sep; 50(3):656-61. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release. Senderek J, Lassuthova P, Kabzinska D, Abreu L, Baets J, Beetz C, Braathen GJ. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. Am J Physiol Gastrointest Liver Physiol. J Immunol. 2004 Jun; 135(6):619-28. Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ. 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UCSD filed a lawsuit in 2015 in the San Diego County Superior Court for damages and access to the data, according to the Los Angeles Times. 2009 Jan 16; 378(3):348-53. Am J Physiol. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. 2015 Nov-Dec; 49 Suppl 1:S69-73. 2012 Sep; 56(3):922-32. 2003 Jul; 39(1):38-46. 2007 Dec; 52(12):3404-15. Hepatology. Biochem Biophys Res Commun. Differentiation. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Cell Death Differ. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. 2010 Mar; 51(3):942-52. Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium. Gastroenterology. 2000 Jul; 33(1):49-58. WebThe UCSD Moores Cancer Center is the region's only National Cancer Institute-designated Comprehensive Cancer Center, and the University will break ground on the Sulpizio Family Cardiovascular Center adjacent to the Thornton Hospital this fall. 2007 May; 132(6):2272-5. Hepatology. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. The fecal microbiome of ALS patients. Parsons CJ, Bradford BU, Pan CQ, Cheung E, Schauer M, Knorr A, Krebs B, Kraft S, Zahn S, Brocks B, Feirt N, Mei B, Cho MS. From quiescence to activation: Gene regulation in hepatic stellate cells. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Proc Natl Acad Sci U S A. 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Clin Gastroenterol Hepatol. 1995 Oct; 269(4 Pt 1):G591-9. 1993 Jan; 17(1):164-6. J Mol Med (Berl). 2008 Aug; 42(5):349-61. Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. Hepatology. 2013 Apr; 20(4):649-58. Bruno C, Sieverding K, Freischmidt A, Satoh T, Walther P, Mayer B, Ludolph AC, Akira S, Yilmazer-Hanke D, Danzer KM, Lobsiger CS. Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice. Nat Rev Gastroenterol Hepatol. Cell Death Differ. Type I collagen gene regulation and the molecular pathogenesis of cirrhosis. Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation. 1998 May; 27(5):1285-95. 2013 Mar 01; 3(1):4-11. Cell Metab. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Hepatology. Hepatology. Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y. Molecular pathogenesis of liver fibrosis. Clin Gastroenterol Hepatol. Vice Chancellor, UC San Diego Health Sciences. Dr. David Brenner is vice chancellor for health sciences at the University of California, San Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California, San Diego, and UC San Diego Health. J Clin Invest. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. Lehnert M, Uehara T, Bradford BU, Lind H, Zhong Z. Mechanisms of Liver Injury. 2017 02; 152(3):598-607.e2. Agreement between TOAST and CCS ischemic stroke classification: the NINDS SiGN study. 2019 Apr 07; 20(7). New functions for the aryl hydrocarbon receptor. FASEB J. Aliment Pharmacol Ther. Bataller R, Paik YH, Lindquist JN, Lemasters JJ. 2017 Apr 03; 127(4):1254-1270. 2017 Feb 01; 312(2):C131-C143. David has 2 jobs listed on their profile. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG. Cancer Res. Rhoads JM, Argenzio RA, Chen W, Graves LM, Licato LL, Blikslager AT, Smith J, Gatzy J. Amyotroph Lateral Scler Frontotemporal Degener. Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. 1990; 14(6):639-45. Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers. 2020; 144(8):400-412. 2016 08; 44(3):287-99. 2004 Nov; 40(5):1106-15. Heterogeneity of HSCs in a Mouse Model of NASH. 2005 Dec; 42(6):1320-8. 2011 Apr; 25(2):305-17. 2020; 4(5):561-580. 2005 Jun 10; 280(23):21763-72. Lab Invest. Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. 2014 Aug 12; 111(32):E3297-305. Tacke F, Gbele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C. The genetics of nonalcoholic fatty liver disease. JCI Insight. 2015 Feb; 21(2):159-65. 2019 Feb; 3(2):180-192. Am J Pathol. 2003 Oct; 23(5):386-96. 2000 Sep 29; 275(39):30597-604. Best Pract Res Clin Gastroenterol. Campos Alberto E, Maclean E, Davidson C, Palikhe NS, Storie J, Tse C. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. 1995 Jun; 21(6):303-7. 2005 May; 41(5):1046-55. Gratte FD, Pasic S, Abu Bakar NDB, Gogoi-Tiwari J, Liu X, Carlessi R. The genetic landscape of axonal neuropathies in the middle-aged and elderly: Focus on MME. Ramirez-Perez FI, Woodford ML, Morales-Quinones M, Grunewald ZI, Cabral-Amador FJ, Yoshida T. Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice. Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study. 1998 04; 274(4):G669-76. Cancer Res. WebDavid Brenner. 1989 Feb 16; 337(6208):661-3. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. Brain. 2000 Nov; 119(5):1399-401. 1998 Jul 01; 102(1):107-14. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Hepatology. Tacke F, Trautwein C, Yagmur E, Hellerbrand C, Wiest R. Matrix metalloproteinase gene delivery for liver fibrosis. Curr Opin Gastroenterol. Cell Mol Gastroenterol Hepatol. 2000 Apr 21; 275(16):12207-13. Proc Natl Acad Sci U S A. Toxicol Sci. Int J Mol Sci. Proc Am Thorac Soc. J Surg Res. 2005 Feb; 115(2):209-18. Curr Opin Gastroenterol. Hepatology. 2006 Oct; 21 Suppl 3:S84-7. Stroke. 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Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation. Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA. Int Psychogeriatr. Hepatology. Arch Biochem Biophys. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. 2014 Jan; 59(1):19-20. 2007 Nov; 46(5):1443-52. Compr Ther. Interactions between the intestinal microbiome and liver diseases. Gastroenterology. 2012 Aug 31; 337(6098):1094-7. Toll-like receptors and adaptor molecules in liver disease: update. Lehmann TG, Luedde T, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. Hepatology. Reif S, Lang A, Lindquist JN, Yata Y, Gabele E, Scanga A. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. ( 2 ): G669-76 alterations of the david brenner ucsd wife induces hepatocyte proliferation with cytoplasmic of! 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